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[Modification of the radiosensitizing effect of metronidazole by 5-fluorouracil and caffeine].

作者信息

Esel'baeva G O, Ermekova S A

出版信息

Radiobiologiia. 1986 Mar-Apr;26(2):271-3.

PMID:3754643
Abstract

A study was made of the combined effect of 5-fluorouracil, metronidazole, caffeine and radiation on radiosensitivity of Pliss lymphosarcoma and protein synthesis rate during the first few hours following irradiation. A complete regression of the tumor was noted in 100% of animals after a 3-fold exposure. Effective postirradiation inhibition of protein synthesis was achieved by injection of metronidazole and caffeine together with 5-fluorouracil.

摘要

相似文献

1
[Modification of the radiosensitizing effect of metronidazole by 5-fluorouracil and caffeine].
Radiobiologiia. 1986 Mar-Apr;26(2):271-3.
2
[Effect of the combined action of metronidazole and cycloheximide on protein synthesis and tumor regression following irradiation].
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3
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Contribution to some radiobiological aspects of the investigation of radiosensitizers of hypoxic cells. Part IV: Radiosensitizing effect of metronidazole evaluated on the level of postirradiation changes of bone marrow cellularity in rats protected by induced hypoxia of lower body half.
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