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护理干预对肾细胞癌术后使用白细胞介素-2和重组人干扰素治疗效果的影响

The Impact of Nursing Interventions on the Treatment Outcomes of Renal Cell Carcinoma with Postoperative Interleukin-2 and Recombinant Human Interferon.

作者信息

Guo Li, Zhao Li-Qin, Chen Jin-Yu, Li Ming

机构信息

Third Department of General Surgery (Breast Armor Surgery), Ezhou Central Hospital, Ezhou City, 436000, People's Republic of China.

Department of Oncology, Ezhou Central Hospital, Ezhou City, 436000, People's Republic of China.

出版信息

J Multidiscip Healthc. 2024 Feb 17;17:735-741. doi: 10.2147/JMDH.S447537. eCollection 2024.

Abstract

OBJECTIVE

This study investigates the impact of nursing interventions on treatment outcomes and adverse reaction rates in renal cell carcinoma (RCC) patients treated postoperatively with Interleukin-2 and recombinant human Interferon.

METHODS

In a retrospective analysis of 90 RCC patients, 43 received standard care (control group), while 47 received additional nursing interventions (intervention group), including psychological care, vital signs monitoring, dietary care, adverse reaction management, and post-discharge care. Patients with concurrent major diseases or other malignancies were excluded. Key assessments included clinical symptom improvement, treatment efficacy, and postoperative adverse reactions.

RESULTS

Among the 90 participants, no significant demographic differences were found between the two groups. The intervention group showed significant improvements in fever resolution, leukocyte normalization, and shorter hospital stays. The overall treatment effectiveness was similar in both groups (90.7% in the intervention group vs 91.5% in the control group). However, the intervention group experienced significantly fewer postoperative adverse reactions, including fever, gastrointestinal symptoms, bone marrow suppression, and neurological abnormalities (6.3% vs 23.2%).

CONCLUSION

The study suggests that nursing interventions can improve treatment outcomes by reducing postoperative adverse reactions in RCC patients receiving postoperative Interleukin-2 and recombinant human Interferon. The overall effectiveness of treatment and care was comparable between the groups. Further extensive studies are needed to confirm these findings and fully understand the impact of nursing interventions on RCC patient outcomes.

摘要

目的

本研究调查了护理干预对接受白细胞介素-2和重组人干扰素术后治疗的肾细胞癌(RCC)患者治疗效果和不良反应发生率的影响。

方法

对90例RCC患者进行回顾性分析,43例接受标准护理(对照组),47例接受额外的护理干预(干预组),包括心理护理、生命体征监测、饮食护理、不良反应管理和出院后护理。排除合并重大疾病或其他恶性肿瘤的患者。主要评估指标包括临床症状改善情况、治疗效果和术后不良反应。

结果

90名参与者中,两组之间未发现显著的人口统计学差异。干预组在退热、白细胞恢复正常和缩短住院时间方面有显著改善。两组的总体治疗效果相似(干预组为90.7%,对照组为91.5%)。然而,干预组术后不良反应明显较少,包括发热、胃肠道症状、骨髓抑制和神经异常(6.3%对23.2%)。

结论

该研究表明,护理干预可通过减少接受术后白细胞介素-2和重组人干扰素治疗的RCC患者的术后不良反应来改善治疗效果。两组治疗和护理的总体效果相当。需要进一步进行广泛研究以证实这些发现,并充分了解护理干预对RCC患者预后的影响。

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本文引用的文献

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Characteristics of self-care interventions for patients with a chronic condition: A scoping review.
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