Ouyang Dijun, Sun Huanhuan, Chen Nan, Yan Yan, Ma Haiqing, Xia Jianchuan
Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China.
Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong, China.
J Oncol. 2022 Jul 30;2022:1587365. doi: 10.1155/2022/1587365. eCollection 2022.
Rare research of renal cell carcinoma (RCC) has been made in a comprehensive and full description based on a long period of time as yet. This study was aimed at investigating the incidence and relative survival rates (RSRs) of RCC in the past forty years and to disclose the impact of sex, race, and socioeconomic status (SES) on RCC.
The data as variables, including age, gender, race, and SES, were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. SES was divided into three levels: low poverty, medium poverty, and high poverty. The medium- and high-poverty groups were integrated into one group in all analyses. The RSRs were calculated using period analysis methodology. Summary statistics including incidence and RSRs were analyzed by Kaplan-Meier and Cox proportional hazards models with GraphPad Prism 8.0.1 software and Stata 12.0 software.
A total of 77,513 patients diagnosed with RCC were enrolled in this study, showing an increased incidence and 10-year RSRs from 1977 to 2016. Patients older than 60 years had the highest incidence and the lowest RSRs. This research also showed significant disparities between different groups: incidence in males, blacks, and medium-high poverty groups was higher than that in females, whites, and low poverty groups, while RSRs were lower. For sex groups, the disparity of RSRs was obvious among patients who were 30-59 years old, but not among those younger than 29 years or older than 60 years. Based on SES, the survival gaps between different SES groups were getting wider over the past forty years.
This study showed how age, sex, race, and SES affected the incidence and RSRs of RCC, which may be beneficial for both better designed clinical trials and efficient prevention methods.
迄今为止，尚未有基于较长时间段对肾细胞癌（RCC）进行全面且完整描述的研究。本研究旨在调查过去40年中RCC的发病率和相对生存率（RSRs），并揭示性别、种族和社会经济地位（SES）对RCC的影响。
从监测、流行病学和最终结果（SEER）数据库中获取包括年龄、性别、种族和SES等变量的数据。SES分为三个水平：低贫困、中等贫困和高贫困。在所有分析中，将中等贫困和高贫困组合并为一组。使用期间分析方法计算RSRs。通过GraphPad Prism 8.0.1软件和Stata 12.0软件，采用Kaplan-Meier和Cox比例风险模型分析包括发病率和RSRs在内的汇总统计数据。
本研究共纳入77513例诊断为RCC的患者，结果显示1977年至2016年发病率和10年RSRs均有所上升。60岁以上患者发病率最高，RSRs最低。本研究还显示不同组之间存在显著差异：男性、黑人以及中等-高贫困组的发病率高于女性、白人以及低贫困组，而RSRs则较低。对于性别组，30-59岁患者的RSRs差异明显，但在29岁以下或60岁以上患者中不明显。基于SES，在过去40年中，不同SES组之间的生存差距越来越大。
本研究表明年龄、性别、种族和SES如何影响RCC的发病率和RSRs，这可能有助于设计更好的临床试验和有效的预防方法。
