Movement, Balance, Performance, and Health Laboratory, Université de Pau & Pays de l'Adour, Tarbes, France.
Pole de Gérontologie Antonin Balmes, CHU de Montpellier; EuroMov Digital Health in Motion, Univ Montpellier, IMT Mines Ales, Alès, France.
Expert Rev Neurother. 2024 Apr;24(4):333-342. doi: 10.1080/14737175.2024.2319766. Epub 2024 Feb 23.
The preventive effects of chronic physical exercise (CPE) on Alzheimer's disease (AD) are now admitted by the scientific community. Curative effects of CPE are more disputed, but they deserve to be investigated, since CPE is a natural non-pharmacological alternative for the treatment of AD.
In this perspective, the authors discuss the impact of CPE on AD based on an exhaustive literature search using the electronic databases PubMed, ScienceDirect and Google Scholar.
Aerobic exercise alone is probably not the unique solution and needs to be complemented by other exercises (physical activities) to optimize the slowing down of AD. Anaerobic, muscle strength and power, balance/coordination and meditative exercises may also help to slow down the AD progression. However, the scientific evidence does not allow a precise description of the best training program for patients with AD. Influential environmental conditions (e.g. social relations, outdoor or indoor exercise) should also be studied to optimize training programs aimed at slowing down the AD progression.
慢性体育锻炼（CPE）对阿尔茨海默病（AD）的预防作用现已被科学界所承认。CPE 的治疗效果存在更多争议，但值得进一步研究，因为 CPE 是治疗 AD 的一种自然的非药物替代方法。
在这篇观点文章中，作者通过使用电子数据库 PubMed、ScienceDirect 和 Google Scholar 进行全面的文献检索，讨论了 CPE 对 AD 的影响。
单纯的有氧运动可能不是唯一的解决方案，需要辅以其他运动（身体活动），以优化 AD 的减缓。无氧运动、肌肉力量和功率、平衡/协调和冥想运动也可能有助于减缓 AD 的进展。然而，科学证据还不能精确描述针对 AD 患者的最佳训练方案。有影响力的环境条件（如社会关系、户外或室内运动）也应加以研究，以优化旨在减缓 AD 进展的训练方案。
