Mahmood Muhammad N
Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AB T6G 2B7, Canada.
Dermatopathology (Basel). 2024 Jan 19;11(1):52-61. doi: 10.3390/dermatopathology11010006.
Direct immunofluorescence is a vital diagnostic test for assessing vesiculobullous disorders, vasculitides, and connective tissue diseases. It is a robust and valuable technique that offers essential diagnostic information for many critical dermatoses. Dermatopathologists depend heavily on the data obtained from direct immunofluorescence evaluation to confirm final diagnoses. Selecting the most appropriate biopsy site is necessary for maximizing diagnostic accuracy, and the best site may vary depending on the clinical differential diagnosis. Inaccurate biopsy site selection can significantly impact the accuracy of the results. To optimize the use of direct immunofluorescence studies, this review provides helpful guidelines and some practical tips for selecting the best biopsy site.
直接免疫荧光检查是评估水疱大疱性疾病、血管炎和结缔组织病的重要诊断试验。它是一项强大且有价值的技术，可为许多关键皮肤病提供重要的诊断信息。皮肤病理学家在很大程度上依赖于直接免疫荧光评估所获得的数据来确诊。选择最合适的活检部位对于最大化诊断准确性是必要的，并且最佳部位可能因临床鉴别诊断而异。活检部位选择不准确会显著影响结果的准确性。为了优化直接免疫荧光检查的使用，本综述提供了有用的指南以及一些选择最佳活检部位的实用技巧。
