Guangzhou Huali Science and Technology Vocational College, Guangzhou, China.
Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, China.
QJM. 2024 Oct 1;117(10):695-708. doi: 10.1093/qjmed/hcae034.
Lysine crotonylation is a newly identified posttranslational modification that is different from the widely studied lysine acetylation in structure and function. In the last dozen years, great progress has been made in lysine crotonylation-related studies, and lysine crotonylation is involved in reproduction, development and disease. In this review, we highlight the similarities and differences between lysine crotonylation and lysine acetylation. We also summarize the methods and tools for the detection and prediction of lysine crotonylation. At the same time, we outline the recent advances in understanding the mechanisms of enzymatic and metabolic regulation of lysine crotonylation, as well as the regulating factors that selectively recognize this modification. Particularly, we discussed how dynamic changes in crotonylation status maintain physiological health and result in the development of disease. This review not only points out the new functions of lysine crotonylation but also provides new insights and exciting opportunities for managing various diseases.
赖氨酸丙二酰化是一种新发现的翻译后修饰，在结构和功能上与广泛研究的赖氨酸乙酰化不同。在过去的十几年中，赖氨酸丙二酰化相关研究取得了巨大进展，赖氨酸丙二酰化参与了生殖、发育和疾病。在这篇综述中，我们强调了赖氨酸丙二酰化和赖氨酸乙酰化之间的相似性和差异性。我们还总结了赖氨酸丙二酰化的检测和预测方法和工具。同时，我们概述了理解赖氨酸丙二酰化酶促和代谢调控机制以及选择性识别这种修饰的调节因子的最新进展。特别地，我们讨论了丙二酰化状态的动态变化如何维持生理健康并导致疾病的发展。这篇综述不仅指出了赖氨酸丙二酰化的新功能，还为各种疾病的治疗提供了新的思路和令人兴奋的机会。
