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Evidence for a single rat thyrotropin-beta-subunit gene: thyroidectomy increases its mRNA.

作者信息

Chin W W, Muccini J A, Shin L

出版信息

Biochem Biophys Res Commun. 1985 May 16;128(3):1152-8. doi: 10.1016/0006-291x(85)91061-7.

DOI:10.1016/0006-291x(85)91061-7
PMID:3839124
Abstract

We have isolated and characterized cDNAs representing the rat thyrotropin-beta-subunit. The cDNAs were prepared from poly(A)+ RNA obtained from rat pituitary glands and encode the precursor of the rat thyrotropin-beta-subunit which contains a leader or signal peptide of 20 amino acids, and an apoprotein of 118 amino acids. Blot hybridization analysis of total rat liver DNA digested with several restriction enzymes indicates the likelihood of a single gene encoding the rat thyrotropin-beta-subunit. In addition, analyses of pituitary RNA from normal and thyroidectomized rats indicate that the mRNA encoding the rat thyrotropin-beta-subunit is approximately 700 bases in length and its level increases 8--10-fold after thyroid gland ablation.

摘要

相似文献

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Biochem Biophys Res Commun. 1985 May 16;128(3):1152-8. doi: 10.1016/0006-291x(85)91061-7.
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引用本文的文献

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Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus.甲状腺激素调节室旁核中促甲状腺激素释放激素信使核糖核酸的水平。
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7329-33. doi: 10.1073/pnas.84.20.7329.
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