Smirnov Anton, Yanushevich Oleg, Krikheli Natella, Solis Pinargote Nestor Washington, Peretyagin Pavel, Grigoriev Sergey, Alou Luis, Sevillano David, López-Piriz Roberto, Guitian Francisco, Bartolomé José Florindo
Spark Plasma Sintering Research Laboratory, Moscow State University of Technology "STANKIN", Vadkovsky per. 1, Moscow 127055, Russia.
Scientific Department, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Delegatskaya St., 20, p. 1, Moscow 127473, Russia.
Antibiotics (Basel). 2024 Feb 9;13(2):175. doi: 10.3390/antibiotics13020175.
The surface adhesion of bacterial cells and the in vivo biocompatibility of a new ceramic-metal composite made of zirconium dioxide and tantalum were evaluated. Within the framework of an in vitro study using the crystal violet staining and colony counting methods, a relatively similar adhesion of to the 3Y-TZP/Ta biocermet (roughness Ra = 0.12 ± 0.04 µm) and Ti-Al6-V4 titanium alloy (Ra = 0.04 ± 0.01 µm) was found. In addition, in an in vivo preliminary study focused on the histological analysis of a series of rods implanted in the jaws of beagle dogs for a six-month period, the absence of any fibrous tissue or inflammatory reaction at the interface between the implanted 3Y-TZP/Ta biocermets and the new bone was found. Thus, it can be concluded that the developed ceramic-metal biocomposite may be a promising new material for use in dentistry.
评估了细菌细胞的表面粘附以及由二氧化锆和钽制成的新型陶瓷-金属复合材料的体内生物相容性。在一项使用结晶紫染色和菌落计数方法的体外研究框架内，发现细菌对3Y-TZP/Ta生物陶瓷（粗糙度Ra = 0.12±0.04 µm）和Ti-Al6-V4钛合金（Ra = 0.04±0.01 µm）的粘附相对相似。此外，在一项体内初步研究中，重点对植入比格犬颌骨六个月的一系列棒材进行组织学分析，发现在植入的3Y-TZP/Ta生物陶瓷与新骨之间的界面处没有任何纤维组织或炎症反应。因此，可以得出结论，所开发的陶瓷-金属生物复合材料可能是一种有前途的牙科新材料。
