Surgical-adjuvant chemotherapy with AMSA in Lewis lung carcinoma bearing mice.

The effect of 4'-(9-Acridinylamino) methanesulfon-m-anisidide (AMSA) in combination with surgery was studied on Lewis lung carcinoma-bearing mice. The surgical removal of the primary tumor was performed at a late stage of growth and the drug was administered i.p. according to different schedules. Results of the present study indicate that the AMSA-surgery combination displays a modest effect against the Lewis lung carcinoma, slightly improved when chemotherapy is given before tumor removal, and that double courses of AMSA, given both before and after surgery, prove to be equally effective as a single preoperative chemotherapy.