Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Health Promotion Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah.
Medicine (Baltimore). 2024 Feb 23;103(8):e37291. doi: 10.1097/MD.0000000000037291.
Recent studies have shown an association between vitamin D deficiency (VDD) and type 2 diabetes mellitus patients (T2DM), but the precise relationship between these conditions has yet to be clarified. In this study, we aimed to estimate the incidence of VDD among diabetic patients and identify any relationship between diabetes and the determinants of VDD among T2DM individuals. A retrospective cross-sectional study was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Patients of either gender were selected from electronic records and checked for vitamin D levels, glycosylated hemoglobin (HbA1c), and other parameters. A total of 864 subjects were enrolled. Subjects were grouped according to HbA1c levels, with < 5.7%, 5.7% to 6.49%, and > 6.5% considered normal, impaired, and diabetic, respectively. VDD was common, with an incidence of 723 (83.7%) subjects. A significantly lower vitamin D level was found in diabetic subjects than in nondiabetic subjects (29.1 ± 12.0 vs 44.0 ± 28.3, P < .001). A total of 207/209 (99%) subjects with impaired HbA1c and 179/183 (97.8%) people with diabetes had VDD. Interestingly, none of the diabetic or impaired HbA1c subjects had normal vitamin D levels. A significant association was found between VDD and being > 50 years old, overweight, or obese, as well as HbA1c, fasting plasma glucose, calcium, and total cholesterol (TC) levels. A high rate of VDD and significantly lower vitamin D levels were found in diabetic subjects. Age, being overweight, obesity, HbA1c, and fasting plasma glucose were the few determinants of VDD among T2DM patients. These findings highlight the importance of addressing vitamin D status in managing and preventing T2DM, particularly in those over the age of 50, those who have higher body weight, and those with raised HbA1c and fasting plasma glucose levels.
最近的研究表明，维生素 D 缺乏症（VDD）与 2 型糖尿病患者（T2DM）之间存在关联，但这些情况之间的确切关系尚未阐明。在这项研究中，我们旨在估计糖尿病患者中 VDD 的发生率，并确定糖尿病与 T2DM 个体中 VDD 决定因素之间的任何关系。这是一项在沙特阿拉伯吉达的阿卜杜勒阿齐兹国王大学医院进行的回顾性横断面研究。从电子病历中选择了男女患者，并检查了维生素 D 水平、糖化血红蛋白（HbA1c）和其他参数。共纳入 864 名受试者。根据 HbA1c 水平将受试者分为三组，分别为<5.7%、5.7%至 6.49%和>6.5%，分别为正常、受损和糖尿病。VDD 很常见，发病率为 723（83.7%）例。糖尿病患者的维生素 D 水平明显低于非糖尿病患者（29.1±12.0 与 44.0±28.3，P<0.001）。207/209（99%）HbA1c 受损和 179/183（97.8%）糖尿病患者均有 VDD。有趣的是，没有糖尿病或 HbA1c 受损的患者的维生素 D 水平正常。VDD 与年龄>50 岁、超重或肥胖以及 HbA1c、空腹血糖、钙和总胆固醇（TC）水平显著相关。糖尿病患者中 VDD 的发生率很高，维生素 D 水平明显较低。年龄、超重、肥胖、HbA1c 和空腹血糖是 T2DM 患者 VDD 的少数决定因素。这些发现强调了在管理和预防 T2DM 中解决维生素 D 状态的重要性，特别是在年龄>50 岁、体重较高以及 HbA1c 和空腹血糖水平升高的患者中。
