Gupta A, Aslam M, Rathi S, Mishra B K, Bhardwaj S, Jhamb R, Madhu S V
Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism.
Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India.
Exp Clin Endocrinol Diabetes. 2018 Sep;126(9):553-558. doi: 10.1055/s-0043-124076. Epub 2018 Mar 20.
A large proportion of subjects with type 2 diabetes mellitus (T2DM) in India are non-obese. Asian-Indian subjects with diabetes have been shown to have low vitamin D levels. Whether low vitamin D levels and T2DM in Asian-Indians is attributable to the associated obesity as in caucasians is unclear. Hence we studied the association of vitamin D levels and T2DM in Asian-Indians with or without obesity.
Total of 213 subjects were recruited in four groups, group 1-Non-obese diabetic, group 2-Non-obese non-diabetic, group 3-Obese diabetic and group 4-Obese non-diabetic. Subjects recruited under various groups were matched for age and sex. Anthropometry, skin-fold thickness, fasting and postprandial plasma glucose, HbA1c, fasting insulin, lipids and vitamin D levels were measured in all study subjects and were compared between the groups.
Mean age of study population was 41.23±7.43 years. Mean BMI in groups 1,2,3 and 4 was 21.34±1.41, 20.53±2.27, 27.72±2.94 and 27.62±3.37 kg/m respectively. Overall 64.3% study subjects had vitamin D deficiency and 27.7% had insufficient vitamin D levels. Significantly lower vitamin D levels were found in diabetic groups 1 and 3 compared to non-diabetic groups 2 and 4. No significant difference was observed in vitamin D levels between groups 1 and 3. Similarly, no significant difference was observed in vitamin D levels between groups 2 and 4. Vitamin D levels did not show any significant correlation with BMI, waist or body fat.
Vitamin D levels do not appear to be related to obesity in diabetic as well non-diabetic Asian-Indian individuals.
印度很大一部分2型糖尿病（T2DM）患者并非肥胖。有研究表明，患糖尿病的亚洲印度人维生素D水平较低。目前尚不清楚亚洲印度人维生素D水平低和患T2DM是否像高加索人那样归因于相关的肥胖。因此，我们研究了有无肥胖的亚洲印度人维生素D水平与T2DM之间的关联。
共招募了213名受试者，分为四组，第1组为非肥胖糖尿病组，第2组为非肥胖非糖尿病组，第3组为肥胖糖尿病组，第4组为肥胖非糖尿病组。各组招募的受试者在年龄和性别上相匹配。对所有研究对象测量人体测量学指标、皮褶厚度、空腹和餐后血糖、糖化血红蛋白（HbA1c）、空腹胰岛素、血脂和维生素D水平，并在组间进行比较。
研究人群的平均年龄为41.23±7.43岁。第1、2、3和4组的平均体重指数（BMI）分别为21.34±1.41、20.53±2.27、27.72±2.94和27.62±3.37kg/m²。总体而言，64.3%的研究对象存在维生素D缺乏，27.7%的研究对象维生素D水平不足。与非糖尿病组2和4相比，糖尿病组1和3的维生素D水平显著较低。组1和组3之间的维生素D水平未观察到显著差异。同样，组2和组4之间的维生素D水平也未观察到显著差异。维生素D水平与BMI、腰围或体脂均无显著相关性。
在患糖尿病和未患糖尿病的亚洲印度个体中，维生素D水平似乎与肥胖无关。
