使用脱氧氟化物和其他半乳糖苷作为配体探究单克隆IgA J539的结合位点。
Probing the combining site of monoclonal IgA J539 using deoxyfluoro- and other galactosides as ligands.
作者信息
Glaudemans C P, Kovác P
出版信息
Mol Immunol. 1985 Jun;22(6):651-3. doi: 10.1016/0161-5890(85)90094-x.
PMID:3839564
Abstract
IgA J539 is a monoclonal anti beta-(1----6)-D-galactopyranan. Measurement of its affinity with a number of synthetic galactosyl oligosaccharides of that linkage type, in which one or more hydroxyl groups have been replaced by a fluorine atom, confirm the assignment of the relative binding strength of the subsites in the protein for the individual galactosyl residues of the antigen.
摘要
免疫球蛋白A J539是一种单克隆抗β-（1----6）-D-吡喃半乳糖聚糖。通过测量它与多种该连接类型的合成半乳糖基寡糖的亲和力（其中一个或多个羟基已被氟原子取代），证实了蛋白质中各个亚位点对抗原单个半乳糖基残基的相对结合强度。
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