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Monoclonal anti-galactan IgA J 539 binds intercatenarily to its polysaccharide antigen. Observations on the binding of antibody to a macromolecular antigen.

作者信息

Glaudemans C P, Bhattacharjee A K, Manjula B N

出版信息

Mol Immunol. 1986 Jun;23(6):655-60. doi: 10.1016/0161-5890(86)90103-3.

DOI:10.1016/0161-5890(86)90103-3
PMID:3748015
Abstract

Highly purified P. Zopfii galactan of mol. wt 2 X 10(5) binds monoclonal IgA J 539 with a Ka of 5.80 X 10(5) M-1 if the polysaccharide concn is expressed in blocks of 30 galactosyl residues. This is the same Ka as found for the antibody and methyl beta (1,6)-beta-D-galactopyranosyltetraoside, the ligand capable of filling the entire combining area of the immunoglobulin. This same polysaccharide precipitates monomeric IgA J 539 on agar-double diffusion. It is concluded that the antibody binds to intercatenary galactosyl residues of the antigen.

摘要

相似文献

1
Monoclonal anti-galactan IgA J 539 binds intercatenarily to its polysaccharide antigen. Observations on the binding of antibody to a macromolecular antigen.
Mol Immunol. 1986 Jun;23(6):655-60. doi: 10.1016/0161-5890(86)90103-3.
2
Mapping of subsites in the combining area of monoclonal anti-galactan immunoglobulin A J539.单克隆抗半乳聚糖免疫球蛋白A J539结合区域内亚位点的定位
Biochemistry. 1984 Dec 18;23(26):6732-6. doi: 10.1021/bi00321a069.
3
Probing the combining site of monoclonal IgA J539 using deoxyfluoro- and other galactosides as ligands.使用脱氧氟化物和其他半乳糖苷作为配体探究单克隆IgA J539的结合位点。
Mol Immunol. 1985 Jun;22(6):651-3. doi: 10.1016/0161-5890(85)90094-x.
4
Seven structurally different murine monoclonal galactan-specific antibodies show identity in their galactosyl-binding subsite arrangements.七种结构不同的鼠源单克隆半乳聚糖特异性抗体在其半乳糖基结合亚位点排列上表现出一致性。
Mol Immunol. 1987 Apr;24(4):371-7. doi: 10.1016/0161-5890(87)90179-9.
5
Antigen binding properties of purified immunoglobulin A and reconstituted secretory immunoglobulin A antibodies.
J Biol Chem. 1996 Jul 5;271(27):16300-9. doi: 10.1074/jbc.271.27.16300.
6
Observations on the binding of four anti-carbohydrate monoclonal antibodies to their homologous ligands.
J Biol Chem. 1996 Apr 5;271(14):8209-14. doi: 10.1074/jbc.271.14.8209.
7
Characterization of a monoclonal antibody that recognizes an arabinosylated (1-->6)-beta-D-galactan epitope in plant complex carbohydrates.一种识别植物复合碳水化合物中阿拉伯糖基化（1→6）-β-D-半乳聚糖表位的单克隆抗体的特性分析
Carbohydr Res. 1995 Oct 2;275(2):295-307. doi: 10.1016/0008-6215(95)00174-r.
8
Monoclonal IgA J539 binds galactopyranosyl antigens on its surface.单克隆IgA J539在其表面结合吡喃半乳糖基抗原。
Mol Immunol. 1983 Mar;20(3):235-8. doi: 10.1016/0161-5890(83)90061-5.
9
The interaction of two polysaccharides containing beta 1,6-linked galactopyranosyl residues with two monoclonal antigalactan immunoglobulin Fab' fragments.
Mol Immunol. 1981 Feb;18(2):79-84. doi: 10.1016/0161-5890(81)90072-9.
10
A synthetic heptasaccharide reveals the capability of a monoclonal antibody to read internal epitopes of a polysaccharide antigen.
Carbohydr Res. 1990 Aug 15;203(2):253-63. doi: 10.1016/0008-6215(90)80022-u.

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