实验性母体糖尿病对后代血浆胆固醇水平和血管前列环素合成的延迟影响。

Delayed effects of experimental maternal diabetes on plasma cholesterol level and vascular prostacyclin synthesis in the offspring.

作者信息

Bydlowski S P, Yunker R L, Subbiah M T

出版信息

Proc Soc Exp Biol Med. 1985 Sep;179(4):553-7. doi: 10.3181/00379727-179-rc4.

Abstract

The effect of streptozotocin-induced diabetes during pregnancy in rats on prostacyclin synthesis in aorta and heart of offsprings was investigated. Although the aortic and heart syntheses of 6-keto-PGF1 alpha in the offsprings of diabetic rats were not altered at birth, a significant rise in aorta and a decrease in the heart were evident at weaning. At weaning, offsprings of diabetic rats also show a significant rise in plasma cholesterol. These studies show that maternal diabetes might cause effects in the offspring which might become evident in later life.

摘要

研究了链脲佐菌素诱导的大鼠孕期糖尿病对其后代主动脉和心脏中前列环素合成的影响。尽管糖尿病大鼠后代出生时主动脉和心脏中6-酮-前列腺素F1α的合成未发生改变，但断奶时主动脉中该物质显著升高，而心脏中则显著降低。断奶时，糖尿病大鼠后代的血浆胆固醇也显著升高。这些研究表明，母体糖尿病可能会对后代产生影响，这些影响可能在其后期生活中显现出来。