Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea.
Sci Rep. 2024 Feb 23;14(1):4455. doi: 10.1038/s41598-024-54919-8.
Blood urea nitrogen (BUN) to albumin ratio (BAR) is a comprehensive parameter that reflects renal, inflammatory, nutritional, and endothelial functions. BAR has been shown to be associated with various cancers, pneumonia, sepsis, and pulmonary and cardiovascular diseases; however, few studies have been conducted on its association with cerebrovascular diseases. In this study, we evaluated the association between BAR and cerebral small vessel disease (cSVD) in health check-up participants. We assessed consecutive health check-up participants between January 2006 and December 2013. For the cSVD subtype, we quantitatively measured the volume of white matter hyperintensity (WMH) and qualitatively measured the presence of lacune and cerebral microbleeds (CMBs). The BAR was calculated by dividing BUN by albumin as follows: BAR = BUN (mg/dl)/albumin (g/dl). A total of 3012 participants were evaluated. In multivariable linear regression analysis, BAR showed a statistically significant association with WMH volume after adjusting for confounders [β = 0.076, 95% confidence interval (CI): 0.027-0.125]. In multivariable logistic regression analyses, BAR was significantly associated with lacunes [adjusted odds ratio (aOR) = 1.20, 95% CI: 1.00-1.44] and CMBs (aOR = 1.28, 95% CI: 1.06-1.55). BAR was associated with all types of cSVD in the health check-up participants.
血尿素氮（BUN）与白蛋白比值（BAR）是一个综合参数，反映了肾脏、炎症、营养和内皮功能。BAR 与各种癌症、肺炎、败血症以及肺和心血管疾病有关；然而，关于其与脑血管疾病的关系的研究较少。在这项研究中，我们评估了 BAR 与健康体检参与者脑小血管疾病（cSVD）之间的关系。我们评估了 2006 年 1 月至 2013 年 12 月期间连续的健康体检参与者。对于 cSVD 亚型，我们定量测量了脑白质高信号（WMH）的体积，并定性测量了腔隙和脑微出血（CMBs）的存在。BAR 通过将 BUN 除以白蛋白计算得出：BAR = BUN（mg/dl）/白蛋白（g/dl）。共评估了 3012 名参与者。在多变量线性回归分析中，BAR 在调整混杂因素后与 WMH 体积呈统计学显著相关[β=0.076，95%置信区间（CI）：0.027-0.125]。在多变量逻辑回归分析中，BAR 与腔隙明显相关[调整后的优势比（aOR）=1.20，95%CI：1.00-1.44]和 CMBs（aOR=1.28，95%CI：1.06-1.55）。BAR 与健康体检参与者的所有类型 cSVD 均有关联。
