Faculty of Health Sciences, Department of Dentistry, University of Brasília, Brasília, Brazil.
University Hospital of Brasilia, Oral Care Center for Inherited Diseases, Brasília, Brazil.
Clin Oral Investig. 2024 Feb 24;28(3):169. doi: 10.1007/s00784-024-05568-8.
Craniofacial and oral manifestations of Osteogenesis Imperfecta (OI) can affect the functioning of the stomatognathic system and impact the patient's quality of life. The objective of the study was to evaluate the relationship between craniofacial and oral manifestations and the Oral Health-related Quality of Life (OHRQoL) of OI children and adolescents.
A total of 30 OI patients aged eight to fourteen years old followed up at the Oral Care Center for Inherited Diseases were enrolled in the research. OHRQoL was assessed using the short form of the Child Perceptions Questionnaire (CPQ) for eight to ten-year-olds (CPQ) and 11 to 14-year-olds (CPQ). The relationship between the OHRQoL index and its assessment domains, OI types, and the presence of dentinogenesis imperfecta (DI), class III malocclusion, and dental agenesis were evaluated.
The median CPQ score of patients was 5, and there was no significant difference in OHRQoL between children and adolescents, nor associated with the disease severity or the presence of DI. The oral manifestations evaluated did not directly impact the patients' OHRQoL.
The study demonstrated that the perception of OHRQoL is similar for both adolescents and children. The oral symptom was the most relevant domain for the index among patients aged eight to fourteen years while the emotional well-being was the most impacted.
this study makes contributions by indicating that addressing dental care for children and adolescents with OI is important in clinical management and better OHRQoL for this population.
成骨不全症（OI）的颅面和口腔表现会影响口腔颌系统的功能，并影响患者的生活质量。本研究的目的是评估OI 儿童和青少年的颅面和口腔表现与口腔健康相关生活质量（OHRQoL）之间的关系。
共纳入 30 名 8 至 14 岁在遗传性疾病口腔护理中心随访的 OI 患者。采用儿童感知问卷（CPQ）短表评估 OHRQoL，8-10 岁儿童使用 CPQ8-10，11-14 岁儿童使用 CPQ11-14。评估 OHRQoL 指数及其评估领域、OI 类型、牙本质发育不全（DI）、III 类错颌畸形和牙齿缺失与存在的关系。
患者的 CPQ 中位数为 5，青少年的 OHRQoL 无差异，与疾病严重程度或 DI 无关。评估的口腔表现并未直接影响患者的 OHRQoL。
本研究表明，青少年和儿童对 OHRQoL 的感知相似。口腔症状是 8-14 岁患者指数中最相关的领域，而情绪健康是受影响最大的领域。
本研究表明，关注 OI 儿童和青少年的口腔护理对临床管理和提高该人群的 OHRQoL 具有重要意义。
