高危结节病：聚焦于肺部、心脏、肝脏和肾脏的晚期疾病以及钙代谢异常。
High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities.
作者信息
Israël-Biet Dominique, Bernardinello Nicol, Pastré Jean, Tana Claudio, Spagnolo Paolo
机构信息
Service de Pneumologie et Soins Intensifs, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
出版信息
Diagnostics (Basel). 2024 Feb 11;14(4):395. doi: 10.3390/diagnostics14040395.
Although sarcoidosis is generally regarded as a benign condition, approximately 20-30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liver and/or kidneys representing additional life-threatening situations. In this review, we discuss diagnosis and treatment of each of these complications and highlight how the integration of clinical, pathological and radiological features may help predict the development of such high-risk situations in sarcoid patients.
尽管结节病通常被视为一种良性疾病，但约20%-30%的患者会发展为慢性进行性疾病。晚期肺纤维化结节病和心脏受累是结节病发病和死亡的主要原因，肝和/或肾功能衰竭则代表其他危及生命的情况。在本综述中，我们讨论了这些并发症的诊断和治疗，并强调临床、病理和放射学特征的综合如何有助于预测结节病患者发生此类高危情况。
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