Judson Marc A
Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY 12208, USA.
J Clin Med. 2023 Sep 20;12(18):6088. doi: 10.3390/jcm12186088.
The aim of this manuscript is to provide a comprehensive review of the etiology, measurement, and treatment of common pulmonary symptoms associated with sarcoidosis. The assessment of symptoms associated with pulmonary sarcoidosis is an important component of disease management. Some symptoms of pulmonary sarcoidosis are sensitive but nonspecific markers of disease activity, and the absence of such symptoms provides evidence that the disease is quiescent. Although quantifiable objective measurements of pulmonary physiology and chest imaging are important in the assessment of pulmonary sarcoidosis, they correlate poorly with the patient's quality of life. Because the symptoms of pulmonary sarcoidosis directly relate to how the patient feels, they are reasonable endpoints in terms of clinical research and individual patient care. Recently, the symptoms of pulmonary sarcoidosis are capable of being quantified via patient-reported outcome measures and electronic devices. We conclude that a thorough assessment of the symptoms associated with pulmonary sarcoidosis improves patient care because it is a useful screen for manifestations of the disease, provides insight into the pathophysiology of manifestations of sarcoidosis, and may assist in optimizing treatment.
本手稿旨在全面综述结节病相关常见肺部症状的病因、测量方法及治疗。评估肺部结节病相关症状是疾病管理的重要组成部分。肺部结节病的一些症状是疾病活动的敏感但非特异性标志物，而此类症状的缺失表明疾病处于静止期。虽然肺部生理学和胸部影像学的可量化客观测量在评估肺部结节病中很重要，但它们与患者的生活质量相关性较差。由于肺部结节病的症状直接关系到患者的感受，因此在临床研究和个体患者护理方面，它们是合理的终点指标。最近，肺部结节病的症状能够通过患者报告结局测量和电子设备进行量化。我们得出结论，对肺部结节病相关症状进行全面评估可改善患者护理，因为它是疾病表现的有用筛查手段，能深入了解结节病表现的病理生理学，且可能有助于优化治疗。
