Tana Claudio, Bernardinello Nicol, Raffaelli Bianca, Garcia-Azorin David, Waliszewska-Prosół Marta, Tana Marco, Albano Giulio, Cipollone Francesco, Giamberardino Maria Adele, Spagnolo Paolo
Center of Excellence on Headache and Geriatrics Clinic, Study of Rare Disorders, University-Hospital of Chieti, Chieti, Italy.
Cardiac, Thoracic and Vascular, Sciences and Public Health, University of Padova School of Medicine and Surgery, Padua, Italy.
Ann Med. 2025 Dec;57(1):2445191. doi: 10.1080/07853890.2024.2445191. Epub 2024 Dec 26.
There has been significant progress in understanding neurosarcoidosis (NS) as a distinct disorder, which encompasses a heterogeneous group of clinical and radiological alterations which can affect patients with systemic sarcoidosis or manifest isolated.
The healthcare challenges posed by NS and sarcoidosis in general extend beyond their physical symptoms and can include a variety of psychosocial factors, therefore the recognition of main neuropsychiatric symptoms can be useful to approach patients with NS. Methods: For this purpose, databases such as Pubmed, Medline and Pubmed Central (PMC) have been searched.
A correct diagnosis of NS is established by the combination of clinical picture, imaging features and the histopathological finding of non-caseating and non-necrotizing granulomas. After analyzing the current literature, there is a need for specific, case-control, cohort and clinical trials on the psychiatric manifestations of sarcoidosis, because the evaluation of psychological distress (in terms of emotional suffering e.g. anxiety or depression) is often underestimated.
Exploring the neuropsychiatric manifestations of sarcoidosis is useful to raise awareness of this condition among clinicians and to establish a holistic management, which includes both physical and psychological aspects.
在将神经结节病（NS）理解为一种独特疾病方面已取得重大进展，它涵盖了一组异质性的临床和放射学改变，这些改变可影响系统性结节病患者或单独出现。
NS以及一般结节病所带来的医疗挑战不仅限于其身体症状，还可能包括多种心理社会因素，因此识别主要的神经精神症状对治疗NS患者可能有用。方法：为此，检索了如PubMed、Medline和PubMed Central（PMC）等数据库。
通过结合临床表现、影像学特征以及非干酪样和非坏死性肉芽肿的组织病理学发现来确诊NS。在分析当前文献后，需要针对结节病的精神表现开展特定的病例对照、队列和临床试验，因为心理困扰（如焦虑或抑郁等情绪痛苦方面）的评估常常被低估。
探索结节病的神经精神表现有助于提高临床医生对这种疾病的认识，并建立包括身体和心理方面的整体管理。
