Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, University Kebangsaaan Malaysia, Jalan Yaacob Latiff, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, Malaysia.
Int J Mol Sci. 2024 Feb 19;25(4):2444. doi: 10.3390/ijms25042444.
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review aims to highlight the latest research findings on the therapeutic mechanisms of action of EVs in SLE. Relevant research articles were identified using the PRISMA framework from databases such as PubMed/MEDLINE (National Library of Medicine), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) from July 2023 to October 2023. Eleven studies met the inclusion criteria and thus were included in this scoping review. The findings showed that EVs have therapeutic effects on ameliorating the disease progression of SLE. EVs can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. The scoping review has successfully analysed the therapeutic potential in ameliorating the disease progression of SLE. The review also includes prospects to improve the effects of EVs further to increase the therapeutic effects on SLE.
系统性红斑狼疮 (SLE) 是一种影响全球近 341 万人的多系统自身免疫性疾病，其中 90%的病例发生在育龄妇女。由于各种免疫途径和机制的相互作用，SLE 是一种复杂的疾病。本范围综述旨在强调 EV 在 SLE 治疗作用机制方面的最新研究结果。使用 PRISMA 框架从数据库（如美国国立医学图书馆的 PubMed/MEDLINE、爱思唯尔的 Scopus 和科睿唯安的 Web of Science: Core Collection）中确定了相关研究文章，检索时间为 2023 年 7 月至 2023 年 10 月。有 11 项研究符合纳入标准，因此被纳入本范围综述。研究结果表明，EV 对改善 SLE 的疾病进展具有治疗作用。EV 可以减少促炎细胞因子并增加抗炎细胞因子。此外，EV 可以增加调节性 T 细胞的水平，从而减少炎症。EV 还具有调节 B 细胞的潜力，以减轻 SLE 并减少其不良反应。本范围综述成功分析了改善 SLE 疾病进展的治疗潜力。该综述还包括进一步提高 EV 效果的前景，以增加对 SLE 的治疗效果。
