Department of Clinical Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
New York-Marche Structural Biology Center (NY-MaSBiC), Polytechnic University of Marche, 60131 Ancona, Italy.
Biomolecules. 2024 Feb 9;14(2):208. doi: 10.3390/biom14020208.
Paraoxonase-2 (PON2) is a ubiquitously expressed intracellular protein that is localized in the perinuclear region, the endoplasmic reticulum (ER), and mitochondria, and is also associated with the plasma membrane. PON2 functions as an antioxidant enzyme by reducing the levels of reactive oxygen species (ROS) in the mitochondria and ER through different mechanisms, thus having an anti-apoptotic effect and preventing the formation of atherosclerotic lesions. While the antiatherogenic role played by this enzyme has been extensively explored within endothelial cells in association with vascular disorders, in the last decade, great efforts have been made to clarify its potential involvement in both blood and solid tumors, where PON2 was reported to be overexpressed. This review aims to deeply and carefully examine the contribution of this enzyme to different aspects of tumor cells by promoting the initiation, progression, and spread of neoplasms.
对氧磷酶 2（PON2）是一种广泛表达的细胞内蛋白，定位于核周区、内质网（ER）和线粒体，也与质膜相关。PON2 通过不同的机制作为抗氧化酶发挥作用，通过减少线粒体和 ER 中的活性氧（ROS）水平，从而具有抗细胞凋亡作用，并防止动脉粥样硬化病变的形成。虽然这种酶的抗动脉粥样硬化作用已在与血管疾病相关的内皮细胞中得到广泛研究，但在过去十年中，人们做出了巨大努力来阐明其在血液和实体肿瘤中的潜在作用，据报道，PON2 在血液和实体肿瘤中过度表达。本综述旨在通过促进肿瘤的发生、进展和扩散，深入细致地研究该酶对肿瘤细胞不同方面的贡献。
