Agarwal Vinayak, Cheesman Matthew, Haywood Alison, Khan Sohil, Dukie Shailendra Anoopkumar
School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Australia.
Mater Research Institute, The University of Queensland, Brisbane, Australia.
J Cancer Res Clin Oncol. 2025 Aug 12;151(8):229. doi: 10.1007/s00432-025-06282-y.
Paraoxonase 2 (PON2), a mitochondrial antioxidant enzyme, is widely expressed across body tissues and plays vital roles in cellular defence. Growing evidence links its dysregulation to oxidative stress and cancer progression. This narrative review aims to elucidate PON2's enzymatic characteristics and explore its potential modulation as an innovative therapeutic avenue for combating cancer.
This narrative review provides a comprehensive evaluation of the roles of paraoxonase 2 in cancer, with a focus on its regulatory mechanisms and potential utility as a biomarker for targeted therapeutic interventions. A comprehensive analysis of the scientific literature from 1924 to 2024 was carried out, with studies retrieved from PubMed, Web of Science, and Scopus. Following a comprehensive screening process, 27 studies were included in the review.
The outcomes underscore PON2's complex involvement in cancer biology, spanning tumour initiation, progression, and therapeutic resistance. The antioxidant attributes of PON2 play a critical role in helping cancer cells combat chemotherapy by allowing them to sustain oxidative stress. PON2 regulates essential features of the cancer cell lifecycle, such as invasion, migration, and proliferation. Its impact on apoptosis makes it promising as a biomarker for prognosis and diagnostics as well as a therapeutic target, especially for patients with drug-resistant cancers.
This review highlights PON2's involvement in carcinogenesis in detail. Future research should focus on elucidating the molecular mechanisms regulating PON2 and exploring its potential as a target for the development of effective cancer therapies.
对氧磷酶2（PON2）是一种线粒体抗氧化酶，在人体组织中广泛表达，在细胞防御中发挥重要作用。越来越多的证据表明，其失调与氧化应激和癌症进展有关。本叙述性综述旨在阐明PON2的酶学特性，并探索将其作为对抗癌症的创新治疗途径进行潜在调控的可能性。
本叙述性综述全面评估了对氧磷酶2在癌症中的作用，重点关注其调节机制以及作为靶向治疗干预生物标志物的潜在用途。对1924年至2024年的科学文献进行了全面分析，研究从PubMed、科学网和Scopus中检索。经过全面筛选过程，27项研究被纳入综述。
结果强调了PON2在癌症生物学中的复杂参与，涵盖肿瘤起始、进展和治疗耐药性。PON2的抗氧化特性在帮助癌细胞对抗化疗方面起着关键作用，使它们能够承受氧化应激。PON2调节癌细胞生命周期的基本特征，如侵袭、迁移和增殖。其对细胞凋亡的影响使其有望成为预后和诊断的生物标志物以及治疗靶点，特别是对于耐药性癌症患者。
本综述详细强调了PON2参与致癌作用。未来的研究应侧重于阐明调节PON2的分子机制，并探索其作为有效癌症治疗开发靶点的潜力。
