School of Life Science, Zhengzhou University, Zhengzhou 450001, China.
Children's Hospital Affiliated of Zhengzhou University, Zhengzhou 450018, China.
Biomolecules. 2024 Feb 11;14(2):214. doi: 10.3390/biom14020214.
The protein 4.1R is an essential component of the erythrocyte membrane skeleton, serving as a key structural element and contributing to the regulation of the membrane's physical properties, including mechanical stability and deformability, through its interaction with spectrin-actin. Recent research has uncovered additional roles of 4.1R beyond its function as a linker between the plasma membrane and the membrane skeleton. It has been found to play a crucial role in various biological processes, such as cell fate determination, cell cycle regulation, cell proliferation, and cell motility. Additionally, 4.1R has been implicated in cancer, with numerous studies demonstrating its potential as a diagnostic and prognostic biomarker for tumors. In this review, we provide an updated overview of the gene and protein structure of 4.1R, as well as its cellular functions in both physiological and pathological contexts.
蛋白 4.1R 是红细胞膜骨架的重要组成部分，作为关键的结构元件，通过与血影蛋白-肌动蛋白的相互作用，参与调节膜的物理性质，包括机械稳定性和变形性。最近的研究揭示了 4.1R 除了作为质膜和膜骨架之间的连接物的功能之外的其他作用。它在各种生物学过程中起着至关重要的作用，如细胞命运决定、细胞周期调节、细胞增殖和细胞迁移。此外，4.1R 与癌症有关，许多研究表明它有作为肿瘤诊断和预后生物标志物的潜力。在这篇综述中，我们提供了 4.1R 的基因和蛋白质结构以及在生理和病理环境中的细胞功能的最新概述。
