Pancreatitis Center East, Gastrounit, Copenhagen University Hospital-Amager and Hvidovre, 2000 Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, 2000 Copenhagen, Denmark.
Biomolecules. 2024 Feb 18;14(2):239. doi: 10.3390/biom14020239.
Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden. In this setting, early detection is of great importance. Due to the anatomy and risks associated with direct sampling from pancreatic tissue, most of our information on the human pancreas arises from circulating biomarkers thought to be involved in pancreatic pathophysiology or injury. The present review provides the status of circulating biomarkers involved in the development of and progression to CP.
慢性胰腺炎（CP）是胰腺从急性胰腺炎反复发作，到早期和最终的终末期 CP 的持续炎症和纤维化的终末阶段。目前，预防是减轻疾病负担的唯一途径。在这种情况下，早期发现非常重要。由于直接从胰腺组织取样的解剖结构和风险，我们对人类胰腺的大部分信息都来自于循环生物标志物，这些标志物被认为与胰腺病理生理学或损伤有关。本文综述了参与 CP 发生和进展的循环生物标志物的现状。
