South Miyagi Medical Center.
Tohoku J Exp Med. 2019 Aug;248(4):225-238. doi: 10.1620/tjem.248.225.
Chronic pancreatitis (CP) is a pancreatic disease with poor prognosis characterized clinically by abdominal pain, morphologically by pancreatic stones/calcification, duct dilatation and atrophy, and functionally by pancreatic exocrine and endocrine insufficiency. CP is also known as a risk factor for the development of pancreatic cancer. CP has long been understood based on a fixed disease concept deduced from the clinical and morphological features of the end-stage disease. However, identification of causal genes for hereditary pancreatitis and success in the isolation and culture of pancreatic stellate cells have advanced the understanding of the underlying pathological mechanisms, the early-stage pathophysiology, and the mechanisms behind pancreatic fibrosis. These advances have led to moves aimed at improving patient prognosis through prevention of disease progression by early diagnosis and early therapeutic intervention. The strategy for preventing disease progression has included a proposal for diagnostic criteria for early CP and introduction of a new definition of CP in consideration of the pathological mechanisms. Our group has been committed deeply to these studies and has provided a large amount of information to the world.
慢性胰腺炎（CP）是一种预后不良的胰腺疾病，临床上以腹痛为特征，形态上以胰石/钙化、胰管扩张和萎缩为特征，功能上以胰腺外分泌和内分泌功能不全为特征。CP 也是胰腺癌发展的一个危险因素。CP 长期以来一直基于从终末期疾病的临床和形态学特征推断出来的固定疾病概念来理解。然而，遗传性胰腺炎的致病基因的鉴定以及胰腺星状细胞的分离和培养的成功，促进了对潜在病理机制、早期病理生理学以及胰腺纤维化机制的理解。这些进展促使人们通过早期诊断和早期治疗干预来预防疾病进展，从而改善患者的预后。预防疾病进展的策略包括提出早期 CP 的诊断标准，并考虑病理机制引入 CP 的新定义。我们的团队一直致力于这些研究，并向世界提供了大量信息。
