School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University, Changsha 410081, P. R. China.
ACS Appl Bio Mater. 2023 May 15;6(5):1934-1942. doi: 10.1021/acsabm.3c00134. Epub 2023 Apr 9.
There are tricky challenges in tumor therapy due to the hypoxic tumor microenvironment, inevitably inhibiting the treatment efficacy of the traditional photodynamic therapy (PDT), radiation therapy (RT), and sonodynamic therapy (SDT). Herein, to overcome tumor hypoxia limitation, we constructed a near-infrared II (NIR-II) light-triggered thermodynamic therapy (TDT) nanoplatform of Au@mSiO-AIPH@PCM/PEG (ASAPP) by integrating the Au nanorods (Au NRs) and thermally activated alkyl free radical-releasing molecules (AIPH). Au NRs@mSiO was used as a photothermally responsive material and AIPH carrier, and the hot-melt phase-change material (PCM) was used as a capping agent to prevent leakage of AIPH during blood circulation. Upon NIR-II light irradiation, heat-triggered free radical release from AIPH was successfully achieved for killing cancer cells and without oxygen dependence, leading to synergistically enhanced antitumor therapy.
由于肿瘤的缺氧微环境，肿瘤治疗存在一些棘手的挑战，这不可避免地抑制了传统的光动力疗法（PDT）、放射疗法（RT）和声动力疗法（SDT）的治疗效果。在此，为了克服肿瘤缺氧的限制，我们构建了一种近红外 II（NIR-II）光触发的热力学治疗（TDT）纳米平台 Au@mSiO-AIPH@PCM/PEG（ASAPP），该平台整合了金纳米棒（AuNRs）和热激活的无烷基自由基释放分子（AIPH）。AuNRs@mSiO 被用作光热响应材料和 AIPH 载体，而热熔相变材料（PCM）被用作封端剂，以防止 AIPH 在血液循环过程中泄漏。在近红外 II 光照射下，成功地实现了 AIPH 从热触发的自由基释放，用于杀死癌细胞，且无需氧气依赖，从而协同增强了抗肿瘤治疗效果。
