Lafi Zainab, Matalqah Sina, Abu-Saleem Ebaa, Asha Nisreen, Mhaidat Hala, Asha Sherine, Al-Nashash Lara, Janabi Hussein S
Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, PO Box: 19328, Amman, Jordan.
The University of Oklahoma Health Sciences, Oklahoma, USA.
Med Oncol. 2024 Dec 9;42(1):26. doi: 10.1007/s12032-024-02567-3.
The integration of nanotechnology into cancer treatment has revolutionized chemotherapy, boosted its effectiveness while reduced side effects. Among the various nanotherapeutic approaches, metal-organic frameworks (MOFs) stand out as promising carriers for targeted chemotherapy, with the added benefit of enabling combination therapies. MOFs, composed of metal ions or clusters linked by coordination bonds, tackle critical issues in traditional cancer treatments, such as poor stability, limited efficacy, and severe side effects. Their key advantages include customizable size and shape, diverse compositions, controlled porosity, large surface areas, ease of modification, and biocompatibility. This review highlights recent advancements in the use of MOFs for cancer therapy, showcasing their role in both monotherapies and combination strategies. Additionally, it explores the future potential and challenges of MOF-based platforms in tumor treatment.
将纳米技术整合到癌症治疗中彻底改变了化疗，提高了其疗效，同时减少了副作用。在各种纳米治疗方法中，金属有机框架（MOF）作为靶向化疗的有前景的载体脱颖而出，还具有实现联合治疗的额外优势。MOF由通过配位键连接的金属离子或簇组成，解决了传统癌症治疗中的关键问题，如稳定性差、疗效有限和副作用严重等。它们的主要优点包括可定制的尺寸和形状、多样的组成、可控的孔隙率、大表面积、易于修饰以及生物相容性。本综述重点介绍了MOF在癌症治疗应用中的最新进展，展示了它们在单一疗法和联合策略中的作用。此外，还探讨了基于MOF的平台在肿瘤治疗中的未来潜力和挑战。
