Goncharov Evgeniy Nikolaevich, Koval Oleg Aleksandrovich, Nikolaevich Bezuglov Eduard, Engelgard Mikhail, Igorevich Eremin Ilya, Velentinovich Kotenko Konstantin, Encarnacion Ramirez Manuel De Jesus, Montemurro Nicola
Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia.
Department of Neurosurgery, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Biomedicines. 2024 Feb 1;12(2):342. doi: 10.3390/biomedicines12020342.
Various stimulation methods, including electrical, ultrasound, mechanical, and biological interventions, are explored, each leveraging intricate cellular and molecular dynamics to expedite healing. The advent of stromal vascular fraction (SVF) marks a significant stride, offering multifarious benefits in bone healing, from enhanced bone formation to optimal vascular integration, drawing a harmonious balance between innate mechanisms and scientific advancements.
This systematic review was conducted focusing on literature from 2016 to 2023 and encompassing various bone healing stimulation mechanisms like SVF, electrical, ultrasound, and mechanical stimulation. The extracted data underwent meticulous synthesis and analysis, emphasizing comparative evaluations of mechanisms, applications, and outcomes of each intervention.
The reviewed studies reveal the potential of SVF in bone fracture healing, with its regenerative and anti-inflammatory effects. The purification of SVF is crucial for safe therapeutic use. Characterization involves flow cytometry and microscopy. Studies show SVF's efficacy in bone regeneration, versatility in various contexts, and potential for clinical use. SVF appears superior to electrical, ultrasound, and mechanical stimulation, with low complications.
This review compares bone healing methods, including SVF. It provides valuable insights into SVF's potential for bone regeneration. However, due to limited human studies and potential bias, cautious interpretation is necessary. Further research is essential to validate these findings and determine the optimal SVF applications in bone healing.
人们探索了多种刺激方法，包括电刺激、超声刺激、机械刺激和生物干预，每种方法都利用复杂的细胞和分子动力学来加速愈合。基质血管成分（SVF）的出现标志着一项重大进展，它在骨愈合中具有多种益处，从增强骨形成到实现最佳的血管整合，在先天机制和科学进步之间取得了和谐的平衡。
本系统综述聚焦于2016年至2023年的文献，涵盖了诸如SVF、电刺激、超声刺激和机械刺激等多种骨愈合刺激机制。对提取的数据进行了细致的综合和分析，重点是对每种干预措施的机制、应用和结果进行比较评估。
综述研究揭示了SVF在骨折愈合中的潜力，及其再生和抗炎作用。SVF的纯化对于安全的治疗应用至关重要。表征方法包括流式细胞术和显微镜检查。研究表明SVF在骨再生方面的有效性、在各种情况下的多功能性以及临床应用潜力。SVF似乎优于电刺激、超声刺激和机械刺激，并发症较少。
本综述比较了包括SVF在内的骨愈合方法。它为SVF在骨再生方面的潜力提供了有价值的见解。然而，由于人体研究有限且存在潜在偏差，需要谨慎解读。进一步的研究对于验证这些发现并确定SVF在骨愈合中的最佳应用至关重要。
