Bulakh P M, Ranade S M, Kowale C N, Chandorkar A G, Burte N P
Indian J Lepr. 1985 Jan-Mar;57(1):115-23.
The clinical material for our studies of serum total LDH activity and LDH isoenzymes in leprosy included 255 patients consisting of Tuberculoid (74), Lepromatous leprosy (116), and Lepromatous leprosy with lepra reaction (65). 20 patients with suspected DDS resistance and repeated attacks of lepra reactions were selected for Clofazimine studies. All leprosy patients exhibited higher total LDH activity as compared to normals. M/H ratio was significantly increased in patients of Lepromatous leprosy and correlated closely with the clinical severity and advancement of disease. Tuberculoid leprosy patients showed values close to normals. Hence M/H ratio could demarcate two polar types of leprosy i.e. Tuberculoid and Lepromatous leprosy. Clofazimine treatment over a period of one year in patients with suspected DDS resistance and repeated attacks of lepra reaction decreased total LDH activity and M/H ratio considerably. Fall in M/H ratio during Clofazimine treatment could be attributed to the clearance of 'M' subunits by the drug due to removal of blockade of R.E.S. system produced by lepra bacilli.
我们对麻风病人血清总乳酸脱氢酶活性及乳酸脱氢酶同工酶进行研究的临床资料包括255例患者，其中结核样型麻风74例、瘤型麻风116例、伴麻风反应的瘤型麻风65例。选择20例疑似对氨苯砜耐药且反复发生麻风反应的患者进行氯法齐明研究。所有麻风患者的总乳酸脱氢酶活性均高于正常人。瘤型麻风患者的M/H比值显著升高，且与疾病的临床严重程度及进展密切相关。结核样型麻风患者的值接近正常。因此，M/H比值可区分两种极性类型的麻风，即结核样型和瘤型麻风。对疑似对氨苯砜耐药且反复发生麻风反应的患者进行为期一年的氯法齐明治疗，可使总乳酸脱氢酶活性和M/H比值显著降低。氯法齐明治疗期间M/H比值的下降可能归因于该药物清除了“M”亚基，这是由于解除了麻风杆菌对网状内皮系统的阻滞作用。
