Saoji A M, Kelkar S S
Lepr India. 1982 Jan;54(1):62-8.
In an earlier study (Saoji et al, 1980) we looked for anomalous (additional) isoenzymes in homogenates of 17 active and 25 of regressing lepromatous leprosy, three of erythema nodosum leprosum, eight of BT, 19 of TT and one of indeterminate leprosy. Anomalous bands were found in 17 cases. They correlated with large numbers of viable organisms and were thought to originate from Mycobacterium leprae. This communication describes the serum LDH isoenzymes of the same 78 cases. Six of 17 cases with anomalous LDH isoenzymes in tissues showed anomalous bands even in serum samples. The bands were much fainter but had similar mobility in terms of Ef values. Therefore, LDH isoenzymes originating from Mycobacterium leprae were discernible in sera of cases, though not on the same scale as in the tissues.
在一项早期研究中（Saoji等人，1980年），我们在17例活动期瘤型麻风、25例消退期瘤型麻风、3例麻风结节性红斑、8例结核样型麻风、19例结核型麻风以及1例未定类麻风的匀浆中寻找异常（额外）同工酶。在17例中发现了异常条带。它们与大量活的微生物相关，被认为起源于麻风分枝杆菌。本报告描述了同一78例患者的血清乳酸脱氢酶同工酶情况。17例组织中乳酸脱氢酶同工酶异常的患者中有6例在血清样本中也显示出异常条带。这些条带要淡得多，但就埃弗值而言具有相似的迁移率。因此，源自麻风分枝杆菌的乳酸脱氢酶同工酶在患者血清中是可辨别的，尽管程度不如在组织中那样。
