齐墩果酸治疗代谢综合征及相关心血管疾病的作用及机制。

The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases.

机构信息

Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China.

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, The School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

出版信息

Molecules. 2024 Feb 6;29(4):758. doi: 10.3390/molecules29040758.

DOI:10.3390/molecules29040758

PMID:38398510

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10892503/

Abstract

Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs' initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.

摘要

代谢综合征（MetS）和相关心血管疾病（CVDs）对人类健康构成严重威胁。MetS 是一种代谢紊乱，其特征为肥胖、血脂异常和高血压，这些都会增加 CVD 发病和发展的风险。尽管有许多可用于治疗 MetS 和相关 CVDs 的药物，但也会出现一些副作用。鉴于副作用水平较低，人们尝试了许多天然产物来治疗 MetS 和 CVDs。一种五环三萜天然产物，齐墩果酸（OA），已被报道具有许多药理作用，如降血压、降血脂和保肝。OA 在治疗 MetS 和 CVDs 方面具有独特的优势。OA 通过多种途径发挥治疗作用，引起了极大的关注，并在治疗 MetS 和 CVDs 方面发挥了重要作用。因此，在本文中，我们旨在综述 OA 治疗 MetS 和相关 CVDs 的药理作用及潜在机制。