Exercise and Metabolism Research Center, College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua City-321004, Zhejiang, China.
Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan.
Curr Pharm Des. 2021;27(6):761-762. doi: 10.2174/138161282706210222144912.
According to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reached nearly one-quarter of the population, and poses a serious threat to public health. MetS is a cluster of conditions characterized by insulin resistance, hypertension, obesity, and cardiovascular-related risk factors. Various aspects, such as modern lifestyle (diet, sedentary behavior), aging and genes attribute to increasing the morbidity of MetS. While external interventions, prescribed drugs and natural materials play an indispensable role in the management of MetS. Intake of plant-based bioactive compounds and peptide-based drug delivery systems emerge as safe and effective pharmacological approaches to treat MetS complications. Natural biomaterials are able to decrease the adverse effects of drugs and enhance treatment efficiency. In this thematic issue, we explored the beneficial effects of various phytochemicals, marine drugs and cellpenetrating peptides (CPPs)-mediated drug delivery system in the management of MetS and associated disorders. The usage of CPPs in combination with other therapeutic agents like nanoparticles and peptides is a novel and efficient approach to conquer the components in MetS.
根据全球统计数据，代谢综合征（Metabolic Syndrome，MetS）的发病率已接近四分之一，这种多因素疾病对公众健康构成了严重威胁。MetS 是一组以胰岛素抵抗、高血压、肥胖和心血管相关危险因素为特征的病症。现代生活方式（饮食、久坐行为）、老龄化和基因等各个方面都导致 MetS 的发病率不断上升。虽然外部干预、处方药和天然材料在 MetS 的治疗中起着不可或缺的作用。植物源性生物活性化合物和基于肽的药物输送系统作为治疗 MetS 并发症的安全有效的药理学方法已经出现。天然生物材料能够降低药物的不良反应并提高治疗效果。在本期特刊中，我们探讨了各种植物化学物质、海洋药物和细胞穿透肽（CPP）介导的药物输送系统在 MetS 及其相关疾病管理中的有益作用。CPPs 与其他治疗剂（如纳米颗粒和肽）联合使用是克服 MetS 成分的一种新颖有效的方法。
