Department of Biochemistry, North West University, Private Bag X2046, Mmabatho 2735, South Africa.
Molecules. 2017 Nov 13;22(11):1915. doi: 10.3390/molecules22111915.
The increasing demand for natural products as an alternative therapy for chronic diseases has encouraged research into the pharmacological importance of bioactive compounds from plants. Recently, there has been a surge of interest in the therapeutic potential of oleanolic acid (OA) in the prevention and management of chronic diseases. Oleanolic acid is a pentacyclic triterpenoid widely found in plants, including fruits and vegetables with different techniques and chromatography platforms being employed in its extraction and isolation. Several studies have demonstrated the potential therapeutic effects of OA on different diseases and their symptoms. Furthermore, oleanolic acid also serves as a framework for the development of novel semi-synthetic triterpenoids that could prove vital in finding therapeutic modalities for various ailments. There are recent advances in the design and synthesis of chemical derivatives of OA to enhance its solubility, bioavailability and potency. Some of these derivatives have also been therapeutic candidates in a number of clinical trials. This review consolidates and expands on recent reports on the biological effects of oleanolic acid from different plant sources and its synthetic derivatives as well as their mechanisms of action in in vitro and in vivo study models. This review suggests that oleanolic acid and its derivatives are important candidates in the search for alternative therapy in the treatment and management of chronic diseases.
随着人们对天然产物作为慢性病替代疗法的需求不断增加，对植物中具有生物活性的化合物的药理学重要性的研究也受到了鼓励。最近，人们对齐墩果酸（OA）在预防和治疗慢性疾病方面的治疗潜力产生了浓厚的兴趣。齐墩果酸是一种五环三萜，广泛存在于植物中，包括水果和蔬菜，不同的技术和色谱平台被用于其提取和分离。多项研究表明，OA 对不同疾病及其症状具有潜在的治疗作用。此外，齐墩果酸还可以作为开发新型半合成三萜类化合物的框架，这些化合物可能对寻找各种疾病的治疗方法至关重要。目前，OA 的化学衍生物的设计和合成方面取得了一些进展，以提高其溶解度、生物利用度和效力。其中一些衍生物也已成为一些临床试验中的治疗候选药物。本综述总结和扩展了最近关于不同植物来源的齐墩果酸及其合成衍生物的生物学效应的报告，以及它们在体外和体内研究模型中的作用机制。本综述表明，齐墩果酸及其衍生物是寻找替代疗法治疗和管理慢性疾病的重要候选药物。
