Centre for Nutraceuticals, University of Westminster, London W1W6 UW, UK.
Centre for Health and Life Sciences (CHLS), Coventry University, Coventry CV1 5FB, UK.
Nutrients. 2024 Feb 8;16(4):489. doi: 10.3390/nu16040489.
Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator which is naturally produced in the body and found in certain foods. The aim of this study was to assess the effect of a bioavailable formulated form of PEA (Levagen+) on serum BDNF levels and parameters of cognitive function in healthy adults.
A randomised double-blinded placebo-controlled cross-over trial was implemented to measure the effects of a 6-week 700 mg/day course of formulated PEA supplementation versus a placebo. Participants (n = 39) completed pre- and post-assessments of a lab-based cognitive test. Serum samples were collected to measure BDNF concentrations using an immunoassay.
A significant increase in serum BDNF levels was found following PEA supplementation compared with the placebo ( = 0. 0057, d = 0.62). The cognition test battery demonstrated improved memory with PEA supplementation through better first success ( = 0.142, d = 0.54) and fewer errors ( = 0.0287; d = -0.47) on the Paired Associates Learning test.
This was the first study to report a direct beneficial effect of Levagen+ PEA supplementation on memory improvement as well as corresponding increases in circulating neurotrophic marker levels. This suggests that formulated PEA holds promise as an innovative and practical intervention for cognitive health enhancement.
棕榈油酸乙醇酰胺（PEA）是一种内源性大麻素样脂质介质，在体内自然产生，并存在于某些食物中。本研究旨在评估生物可利用形式的 PEA（Levagen+）对健康成年人血清 BDNF 水平和认知功能参数的影响。
采用随机双盲安慰剂对照交叉试验，测量为期 6 周、每天 700mg 的配方 PEA 补充剂与安慰剂的影响。参与者（n=39）完成了基于实验室的认知测试的预评估和后评估。采集血清样本，使用免疫测定法测量 BDNF 浓度。
与安慰剂相比，PEA 补充后血清 BDNF 水平显著升高（=0.0057，d=0.62）。认知测试表明，PEA 补充可改善记忆，表现在配对联想学习测试中首次成功次数增加（=0.142，d=0.54）和错误次数减少（=0.0287；d=-0.47）。
这是第一项报道 Levagen+PEA 补充对记忆改善以及相应增加循环神经营养标志物水平有直接有益影响的研究。这表明配方 PEA 作为一种创新且实用的认知健康增强干预措施具有潜力。
Zotero 插件
