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新型杆状病毒核多角体病毒（CaabNPV）全基因组的测序、分析与组织。

Sequencing, Analysis and Organization of the Complete Genome of a Novel Baculovirus Nucleopolyhedrovirus (CaabNPV).

机构信息

State Key Laboratory of Integrated Management of Pests and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

University of Chinese Academy of Sciences, Beijing 101408, China.

出版信息

Viruses. 2024 Feb 4;16(2):252. doi: 10.3390/v16020252.

DOI:10.3390/v16020252
PMID:38400028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10891889/
Abstract

, a virus family characterized by a single large double stranded DNA, encompasses the majority of viral bioinsecticides, representing a highly promising and environmentally friendly pesticide approach to insect control. This study focuses on the characterization of a baculovirus isolated from larvae of (Erebidae, Lymantriidae) collected in Mongolian pinaceae forests. This new isolate was called nucleopolyhedrovirus (CaabNPV). CaabNPV exhibits an irregular polyhedron shape, and significant variation in the diameter of its occlusion bodies (OBs) was observed. Nucleotide distance calculations confirmed CaabNPV as a novel baculovirus. The CaabNPV genome spans 177,161 bp with a G+C content of 45.12% and harbors 150 potential open reading frames (ORFs), including 38 core genes. A comprehensive genomic analysis categorizes CaabNPV within Group II alphabaculovirus, revealing a close phylogenetic relationship with (OrleNPV). Additionally, repeat sequence analysis identified three highly repetitive sequences consisting of 112 bp repeat units, known as homologous regions (). This research contributes valuable insights into CaabNPV's phylogenetic placement, genomic structure, and its potential applications in insect biocontrol.

摘要

, 一种以单一大型双链 DNA 为特征的病毒家族，包含了大多数病毒生防剂，是一种极具前景且环保的昆虫控制方法。本研究专注于从蒙古松树林中收集的 （夜蛾科、枯叶蛾科）幼虫中分离出的杆状病毒的特性描述。该新分离株被称为 核多角体病毒 (CaabNPV)。CaabNPV 呈现不规则的多面体形状，其包含体 (OBs) 的直径存在显著差异。核苷酸距离计算证实 CaabNPV 为一种新型杆状病毒。CaabNPV 的基因组跨度为 177,161 bp，G+C 含量为 45.12%，包含 150 个潜在的开放阅读框 (ORFs)，其中包括 38 个核心基因。全面的基因组分析将 CaabNPV 归类为 II 组甲型杆状病毒，与 （OrleNPV）密切相关。此外，重复序列分析确定了三个由 112 bp 重复单元组成的高度重复序列，称为同源区 ()。这项研究为 CaabNPV 的系统发育定位、基因组结构以及在昆虫生物防治中的潜在应用提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/6737e4b9d0d0/viruses-16-00252-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/c02ba34b00e1/viruses-16-00252-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/58d68e2cca92/viruses-16-00252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/85d75cbcdc65/viruses-16-00252-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/c736d5132022/viruses-16-00252-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/647db39245ce/viruses-16-00252-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/6737e4b9d0d0/viruses-16-00252-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/c02ba34b00e1/viruses-16-00252-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/58d68e2cca92/viruses-16-00252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/85d75cbcdc65/viruses-16-00252-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/c736d5132022/viruses-16-00252-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/647db39245ce/viruses-16-00252-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10891889/6737e4b9d0d0/viruses-16-00252-g006.jpg

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