Zuerlein N, Denzler T, Schenken J R
Arch Pathol Lab Med. 1985 Oct;109(10):958-60.
Two patients developed adenocarcinoma of the gastric stump 20 to 30 years following gastric resection for benign peptic ulcer disease. The bulk of the medical literature supports a small but definite increased incidence with a latency period of 20 years or more. The risk is greatest following operations that lead to greater reflux of bile and pancreatic juices into the gastric remnant. The diagnosis may be inapparent by upper gastrointestinal tract roentgenograms, and changes may not even be obvious at endoscopy. Five-year survival rates are low (2% to 4%). Because the prognosis is poor once the disease is diagnosed, the high-risk patient should be considered for intermittent endoscopic surveillance.
两名患者在因良性消化性溃疡疾病行胃切除术后20至30年发生了残胃癌。大量医学文献支持发病率虽低但确实有所增加，潜伏期为20年或更长。在导致胆汁和胰液更多反流至胃残端的手术后，风险最大。上消化道X线造影可能无法明确诊断，甚至在内镜检查时变化也可能不明显。五年生存率很低（2%至4%）。由于一旦诊断出该病预后就很差，对于高危患者应考虑进行间歇性内镜监测。
