Wu Liusheng, Li Xiaoqiang, Qian Xinye, Wang Shuang, Liu Jixian, Yan Jun
Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 100084, China.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Vaccines (Basel). 2024 Feb 12;12(2):186. doi: 10.3390/vaccines12020186.
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great research interest. mRNA vaccines are a potential choice for tumor immunotherapy, due to their ability to directly encode antigen proteins and stimulate a strong immune response. However, the mode of delivery and lack of stability of mRNA are key issues limiting its application. LNPs are an excellent mRNA delivery carrier, and their structural stability and biocompatibility make them an effective means for delivering mRNA to specific targets. This study summarizes the research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity. The role of LNPs in improving mRNA stability, immunogenicity, and targeting is discussed. This review aims to systematically summarize the latest research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity to provide new ideas and strategies for tumor immunotherapy, as well as to provide more effective treatment plans for patients.
近年来，脂质纳米颗粒（LNPs）在肿瘤免疫治疗中受到广泛关注。在癌症治疗中靶向免疫细胞已成为一个极具研究兴趣的策略。mRNA疫苗是肿瘤免疫治疗的一个潜在选择，因为它们能够直接编码抗原蛋白并激发强烈的免疫反应。然而，mRNA的递送方式和缺乏稳定性是限制其应用的关键问题。LNPs是一种出色的mRNA递送载体，其结构稳定性和生物相容性使其成为将mRNA递送至特定靶点的有效手段。本研究总结了LNP递送载体辅助的靶向控释mRNA疫苗在肿瘤免疫中的研究进展。讨论了LNPs在提高mRNA稳定性、免疫原性和靶向性方面的作用。这篇综述旨在系统总结LNP递送载体辅助的靶向控释mRNA疫苗在肿瘤免疫中的最新研究进展，为肿瘤免疫治疗提供新思路和策略，并为患者提供更有效的治疗方案。
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