Boman H G, Faye I, von Hofsten P, Kockum K, Lee J Y, Xanthopoulos K G, Bennich H, Engström A, Merrifield R B, Andreu D
Dev Comp Immunol. 1985 Summer;9(3):551-8. doi: 10.1016/0145-305x(85)90018-7.
Diapausing pupae of Cecropia respond to a bacterial infection by the selective synthesis of RNA and 15-20 hemolymph proteins. Of these we have purified lysozyme and two classes of antibacterial proteins called cecropins and attacins. The primary structure has been determined for the lysozyme, one attacin and five cecropins. We have also prepared a cDNA bank, isolated and sequenced clones corresponding to the lysozyme, the two main attacins and one cecropin. The results of these structural studies are briefly summarized. Finally we review the solid phase synthesis of cecropin A and B and 9 analogs of cecropin A.
天蚕滞育蛹通过选择性合成RNA和15 - 20种血淋巴蛋白来应对细菌感染。在这些蛋白中，我们已经纯化出溶菌酶以及两类抗菌蛋白，即天蚕素和攻击素。已经确定了溶菌酶、一种攻击素和五种天蚕素的一级结构。我们还制备了一个cDNA文库，分离并测序了与溶菌酶、两种主要攻击素和一种天蚕素相对应的克隆。简要总结了这些结构研究的结果。最后，我们综述了天蚕素A和B以及天蚕素A的9种类似物的固相合成。
