Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil.
Postgraduate Program in Food Science and Technology, Federal University of Paraíba, João Pessoa, Brazil; Food and Beverage Analysis Laboratory, Department of Food Technology, Instituto Federal do Sertão Pernambucano, Petrolina, Brazil.
Nutrition. 2024 May;121:112370. doi: 10.1016/j.nut.2024.112370. Epub 2024 Feb 1.
The aim of this article is to investigate the effect of intermittent fasting, associated or not with coconut oil intake, on the gut-liver axis of obese rats.
A total of 50 rats were divided into five groups: control, obese, obese with intermittent fasting, obese with intermittent fasting plus coconut oil, and obese with caloric restriction. The rats were induced to obesity with a high-sugar diet for 17 wk. The respective interventions were carried out in the last 4 wk.
The groups with intermittent fasting protocols had reduced total cholesterol (on average 54.31%), low-density lipoprotein (on average 53.39%), and triacylglycerols (on average 23.94%) versus the obese group; and the obese with intermittent fasting plus coconut oil group had the highest high-density lipoprotein compared with all groups. The obese with intermittent fasting plus coconut oil and obese with caloric restriction groups had lower metabolic load compared with the other groups. The obese group had high citric and succinic acid concentrations, which affected the hepatic tricarboxylic acid cycle, while all the interventions had reduced concentrations of these acids. No histologic changes were observed in the intestine or liver of the groups.
Intermittent fasting, especially when associated with coconut oil, had effects comparable with caloric restriction in modulating the parameters of the gut-liver axis.
本文旨在研究间歇性禁食（与或不与椰子油摄入相关联）对肥胖大鼠肠-肝轴的影响。
将 50 只大鼠分为 5 组：对照组、肥胖组、肥胖伴间歇性禁食组、肥胖伴间歇性禁食加椰子油组和肥胖限食组。大鼠通过高糖饮食诱导肥胖 17 周，在最后 4 周进行相应的干预。
与肥胖组相比，间歇性禁食方案组的总胆固醇（平均降低 54.31%）、低密度脂蛋白（平均降低 53.39%）和三酰甘油（平均降低 23.94%）均降低；与所有组相比，肥胖伴间歇性禁食加椰子油组的高密度脂蛋白最高。肥胖伴间歇性禁食加椰子油和肥胖限食组的代谢负荷均低于其他组。肥胖组柠檬酸和琥珀酸浓度较高，影响了肝脏三羧酸循环，而所有干预措施均降低了这些酸的浓度。各组的肠和肝均未观察到组织学变化。
间歇性禁食，特别是与椰子油联合应用，在调节肠-肝轴参数方面具有与热量限制相当的效果。
