Adu-Gymafi Y, Farag H, Naguib M, Gyasi H
Middle East J Anaesthesiol. 1985 Jun;8(2):165-70.
A group of 30 patients undergoing various operative procedures were anesthetized using high dose epidural morphine 20 mg in 15 ml of normal saline, thiopentone induction, endotracheal intubation and muscle relaxation with pancuronium 0.1 mg/kg and controlled ventilation with oxygen and nitrous oxide. Operative conditions and patient acceptance of the technique were satisfactory. There was cardiovascular stability and prolonged postoperative analgesia. Pruritus was observed in three patients and urinary retention in one and were adequately treated. Early mild respiratory depression occurred in one patient and this was treated with naloxone. High dose epidural morphine is efficacious and safe in providing intraoperative and postoperative analgesia.
一组30例接受各种手术操作的患者，采用15毫升生理盐水中含20毫克高剂量硬膜外吗啡进行麻醉，硫喷妥钠诱导，气管插管，0.1毫克/千克泮库溴铵肌肉松弛，并使用氧气和氧化亚氮进行控制通气。手术条件和患者对该技术的接受度令人满意。患者心血管稳定，术后镇痛时间延长。3例患者出现瘙痒，1例出现尿潴留，均得到充分治疗。1例患者出现早期轻度呼吸抑制，用纳洛酮进行了治疗。高剂量硬膜外吗啡在提供术中和术后镇痛方面有效且安全。
