Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cancer Cell. 2024 Mar 11;42(3):325-327. doi: 10.1016/j.ccell.2024.01.008. Epub 2024 Feb 22.
Dozens of compounds that rescue tumor-associated mutant p53 have been reported. Xiao et al. perform 10 assays to evaluate effectiveness of the mutant p53-rescue compounds side-by-side but do not detect reliable rescue in any assay for the evaluated compounds, except for ATO and its analog PAT.
据报道，有数十种化合物可挽救肿瘤相关的突变型 p53。Xiao 等人进行了 10 项测定来评估这些突变型 p53 挽救化合物的效果，但除了 ATO 和其类似物 PAT 之外，在所有评估的化合物中，没有任何一项测定能可靠地挽救突变型 p53。
