Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Curr Opin Biotechnol. 2024 Apr;86:103080. doi: 10.1016/j.copbio.2024.103080. Epub 2024 Feb 24.
Collagen is a primary constituent of the tissue extracellular matrix. As a result, collagen has been a common component of tissue engineering biomaterials, including those to promote bone regeneration or to investigate cell-material interactions in the context of bone homeostasis or disease. This review summarizes key considerations regarding current state-of-the-art design and use of collagen biomaterials for these applications. We also describe strategic opportunities for collagen biomaterials to address a new era of challenges, including immunomodulation and appropriate consideration of sex and other patient characteristics in biomaterial design.
胶原蛋白是组织细胞外基质的主要成分。因此，胶原蛋白一直是组织工程生物材料的常见成分，包括促进骨再生或研究骨稳态或疾病背景下细胞-材料相互作用的生物材料。本文综述了当前设计和使用胶原蛋白生物材料用于这些应用的关键考虑因素。我们还描述了胶原蛋白生物材料应对新时代挑战的战略机遇，包括免疫调节以及在生物材料设计中适当考虑性别和其他患者特征。
