Department of General Surgery, Chun'an First People's Hospital (Zhejiang Provincial People's Hospital Chun'an Branch) , Hangzhou, Zhejiang Province, China.
Department of Orthopedics, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College) , Hangzhou, China.
Organogenesis. 2020 Oct 1;16(4):113-125. doi: 10.1080/15476278.2020.1808428. Epub 2020 Aug 16.
Bone defects or fractures generally heal in the absence of major interventions due to the high regenerative capacity of bone tissue. However, in situations of severe/large bone defects, these orchestrated regeneration mechanisms are impaired. With advances in modern medicine, natural and synthetic bio-scaffolds from bioceramics and polymers that support bone growth have emerged and gained intense research interest. In particular, scaffolds that recapitulate the molecular cues of extracellular signals, particularly growth factors, offer potential as therapeutic bone biomaterials. The current challenges for these therapies include the ability to engineer materials that mimic the biological and mechanical properties of the real bone tissue matrix, whilst simultaneously supporting bone vascularization. In this review, we discuss the very recent innovative strategies in bone biomaterial technology, including those of endogenous biomaterials and cell/drug delivery systems that promote bone regeneration. We present our understanding of their current value and efficacy, and the future perspectives for bone regenerative medicine.
在没有重大干预的情况下，由于骨组织具有较高的再生能力，骨缺损或骨折通常会自行愈合。然而，在严重/大骨缺损的情况下，这些协调的再生机制会受到损害。随着现代医学的进步，天然和合成的生物支架，包括生物陶瓷和聚合物，已经出现并引起了强烈的研究兴趣。特别是那些能够重现细胞外信号分子线索的支架，特别是生长因子，为治疗性骨生物材料提供了潜力。这些疗法目前面临的挑战包括能够设计出模拟真实骨组织基质的生物和机械特性的材料，同时支持骨血管生成。在这篇综述中，我们讨论了骨生物材料技术的最新创新策略，包括内源性生物材料和细胞/药物输送系统，这些策略促进了骨再生。我们介绍了我们对它们目前价值和疗效的理解，以及骨再生医学的未来前景。
