Ferri Nicola, Ravizzotti Elisa, Bracci Alessandro, Carreras Giulia, Pillastrini Paolo, Di Bari Mauro
Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, Italy; Division of Occupational Medicine, IRCCS University Hospital of Bologna S Orsola-Malpighi Polyclinic, Bologna, Italy.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health (DINOGMI), University of Genoa, Genoa, Italy.
J Clin Epidemiol. 2024 May;169:111303. doi: 10.1016/j.jclinepi.2024.111303. Epub 2024 Feb 24.
To assess the confidence in the results of systematic reviews on the effectiveness of physiotherapy for musculoskeletal conditions in the past 10 years and to analyze trends and factors associated.
This is a metaepidemiological study on systematic reviews (SRs) with meta-analysis of randomized controlled trials (RCTs). MEDLINE, Cochrane Database of Systematic Reviews, CINAHL, and PEDro were searched for SRs of RCT on physiotherapy interventions for musculoskeletal disorders from December 2012 to December 2022. Two researchers independently screened the records based on the inclusion criteria; a random sample of 100 studies was selected, and each journal, author, and study variable was extracted. The methodological quality of SRs was independently assessed with the AMSTAR 2 tool. Any disagreement was solved by consensus.
The confidence in SRs results was critically low in 90% of the studies, and it did not increase over time. Cochrane reviews are predominantly represented in the higher AMSTAR 2 confidence levels, with a statistically significant difference compared to non-Cochrane reviews. The last author's H-index is the only predictor of higher confidence among the variables analyzed (OR 1.04; 95% CI: 1.01, 1.06).
The confidence in SRs results is unacceptably low. Given the relevance of musculoskeletal disorders and the impact of evidence synthesis on the clinical decision-making process, there is an urgent need to improve the quality of secondary research by adopting more rigorous methods.
评估过去10年关于物理治疗对肌肉骨骼疾病有效性的系统评价结果的可信度,并分析相关趋势和因素。
这是一项对随机对照试验(RCT)进行荟萃分析的系统评价的元流行病学研究。检索MEDLINE、Cochrane系统评价数据库、CINAHL和PEDro,以获取2012年12月至2022年12月期间关于物理治疗干预肌肉骨骼疾病的RCT的系统评价。两名研究人员根据纳入标准独立筛选记录;随机抽取100项研究,提取每项研究的期刊、作者和研究变量。使用AMSTAR 2工具独立评估系统评价的方法学质量。任何分歧通过协商一致解决。
90%的研究中,对系统评价结果的信心极低,且未随时间增加。Cochrane系统评价在AMSTAR 2较高信心水平中占主导地位,与非Cochrane系统评价相比有统计学显著差异。在分析的变量中,最后一位作者的H指数是较高信心的唯一预测因素(OR 1.04;95%CI:1.01,1.06)。
对系统评价结果的信心低到不可接受。鉴于肌肉骨骼疾病的相关性以及证据综合对临床决策过程的影响,迫切需要采用更严格的方法提高二次研究的质量。