Jing Yin, Shu Rong, Wu Tingting, Liu Dongqi, Luo Xiao, Sun Jun, Chen Fangchun
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China; The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering, Chongqing 401147, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China; The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China.
Photodiagnosis Photodyn Ther. 2024 Apr;46:104026. doi: 10.1016/j.pdpdt.2024.104026. Epub 2024 Feb 23.
To investigate the clinical efficacy of aminovalerate hydrochloride photodynamic therapy (PDT) for oral potentially malignant disorder (OPMD),oral leukoplakia (OLK), along with identifying the influencing factors.Additionally, the study aims to detect the rates of recurrence and malignancy after PDT.
60 patients with OPMD who received PDT at our hospital from 2006 to 2021 were included in this study. Relevant patient medical data were collected and analyzed using SAS 9.4 software.The Mann-Whitney U test was used to retrospectively analyze the factors influencing clinical efficacy, as well as recurrence rate and malignant transformation rate (MTR) after treatment.
Among the 60 OPMD patients receiving PDT, complete remission in 13 (21.67 %), partial remission in 39 (65.00 %), and no remission in eight (13.33 %), resulting in an overall effective rate of 86.67 %.Fifteen patients experienced relapse, leading to a recurrence rate of 25.00 %. Among these relapses,11 patients occurred within one year after treatment, corresponding to an 18.33 % recurrence rate during that period. Moreover, nine patients developed malignant transformation (MT), resulting in an MTR of 15.00 %. Out of these patients, six individuals developed MT within one year after treatment, resulting in a one-year MTR of 10.00 %.
The study findings indicate that PDT shows promising clinical efficacy in the treatment of OPMD, with relatively limited and tolerable postoperative adverse reactions. However, there remains a certain rate of recurrence and malignancy after treatment. Therefore, close attention should be paid to postoperative monitoring, regular follow-up, and further expansion of the sample size to observe its long-term efficacy.
探讨盐酸氨基戊酸光动力疗法（PDT）治疗口腔潜在恶性疾病（OPMD）、口腔白斑（OLK）的临床疗效，并分析其影响因素。此外，本研究旨在检测PDT治疗后的复发率和恶变率。
纳入2006年至2021年在我院接受PDT治疗的60例OPMD患者。收集相关患者的医疗数据，并使用SAS 9.4软件进行分析。采用曼-惠特尼U检验对影响临床疗效、治疗后复发率和恶变率（MTR）的因素进行回顾性分析。
60例接受PDT治疗的OPMD患者中，完全缓解13例（21.67%），部分缓解39例（65.00%），未缓解8例（13.33%），总有效率为86.67%。15例患者复发，复发率为25.00%。其中，11例患者在治疗后1年内复发，该时间段内的复发率为18.33%。此外，9例患者发生恶变，MTR为15.00%。在这些患者中，6例在治疗后1年内发生恶变，1年MTR为10.00%。
研究结果表明，PDT治疗OPMD具有良好的临床疗效，术后不良反应相对有限且可耐受。然而，治疗后仍有一定的复发率和恶变率。因此，应密切关注术后监测、定期随访，并进一步扩大样本量以观察其长期疗效。
