Wang Zhao, Zhang Jun-Ping, Yang Ying-Xi
Chinese Medical College, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300112, China.
Zhongguo Zhong Yao Za Zhi. 2024 Jan;49(2):325-333. doi: 10.19540/j.cnki.cjcmm.20231101.601.
Neutrophil extracellular traps(NETs) are fibrous networks formed by neutrophils after a procedure called NETosis, with the function of capturing and killing pathogens. NETs are widely involved in the pathological processes of major diseases such as immune system diseases, respiratory diseases, metabolic diseases, cancers, and reperfusion injury. Therefore, regulating NETs has become one of the important ways to prevent and treat the above diseases. As an excellent traditional culture in China, traditional Chinese medicine has made outstanding contributions to the treatment of diseases. In recent years, studies have discovered that a variety of active components in traditional Chinese medicines, Chinese medicine compound prescriptions, and single traditional Chinese medicines can alleviate the symptoms by regulating NETs in the pathological process of major diseases. This article reviews the research progress in the regulation of NETs by the active components of traditional Chinese medicines, Chinese medicine compound prescriptions, and single traditional Chinese medicines in the last five years, aiming to serve as a reference for related research.
中性粒细胞胞外陷阱（NETs）是中性粒细胞在经历一种名为NETosis的过程后形成的纤维网络，具有捕获和杀死病原体的功能。NETs广泛参与免疫系统疾病、呼吸系统疾病、代谢性疾病、癌症和再灌注损伤等重大疾病的病理过程。因此，调节NETs已成为预防和治疗上述疾病的重要途径之一。作为中国优秀的传统文化，中医药在疾病治疗方面做出了杰出贡献。近年来，研究发现中药、中药复方和单味中药中的多种活性成分可通过调节重大疾病病理过程中的NETs来缓解症状。本文综述了近五年来中药、中药复方和单味中药活性成分对NETs调节作用的研究进展，旨在为相关研究提供参考。
