Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.
Department of Gastroenterology, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, 350025, China.
Orphanet J Rare Dis. 2024 Feb 25;19(1):88. doi: 10.1186/s13023-024-03064-6.
Metformin has been reported to inhibit the occurrence and development of colorectal cancer (CRC) by mediating changes in intestinal flora. Studies have also indicated that the occurence of familial adenomatous polyposis (FAP) may also be associated with changes in the intestinal flora. Therefore, we investigated the efficacy and safety of metformin in treating FAP and the association with intestinal flora.
Compared with the baseline, the mean number and load of polyps in the areas of nanocarbon labeling and postoperative residuals in the test group were lower than those in the placebo group, while the diversity of intestinal flora species was increased. At the genus level, the relative abundance of g_Ruminococcus in the test group was lower than that at baseline, whereas the relative abundance of g_Lactobacillus was higher. These changes were statistically significant (P < 0.05).
One-year metformin therapy for FAP is safe and effective, potentially mediated by modulating the intestinal flora. This study provides new insights and strategies for preventing adenomatous polyp carcinogenesis in FAP and explores possible preventive action.
二甲双胍通过介导肠道菌群的变化，已被报道可抑制结直肠癌（CRC）的发生和发展。研究还表明，家族性腺瘤性息肉病（FAP）的发生也可能与肠道菌群的变化有关。因此，我们研究了二甲双胍治疗 FAP 的疗效和安全性及其与肠道菌群的关系。
与基线相比，实验组纳米碳标记区域和术后残端的息肉数量和负荷平均值均低于安慰剂组，而肠道菌群物种的多样性增加。在属水平上，实验组 g_Ruminococcus 的相对丰度低于基线，而 g_Lactobacillus 的相对丰度较高。这些变化具有统计学意义（P<0.05）。
FAP 患者应用一年二甲双胍治疗是安全有效的，可能通过调节肠道菌群来介导。本研究为预防 FAP 腺瘤性息肉癌变提供了新的见解和策略，并探讨了可能的预防作用。
