Cao Hai-Ling, Wei Wei, Meng Ya-Jing, Deng Ren-Hao, Li Xiao-Jing, Deng Wei, Liu Yan-Song, Tang Zhen, Du Xiang-Dong, Greenshaw Andrew J, Li Ming-Li, Li Tao, Guo Wan-Jun
Mental Health Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Department of Neurobiology, Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310063, China.
Eur Arch Psychiatry Clin Neurosci. 2025 Mar;275(2):439-449. doi: 10.1007/s00406-024-01760-9. Epub 2024 Feb 26.
There is inconsistent evidence for an association of obesity with white matter microstructural alterations. Such inconsistent findings may be related to the cumulative effects of obesity and alcohol dependence. This study aimed to investigate the possible interactions between alcohol dependence and overweight/obesity on white matter microstructure in the human brain. A total of 60 inpatients with alcohol dependence during early abstinence (44 normal weight and 16 overweight/obese) and 65 controls (42 normal weight and 23 overweight/obese) were included. The diffusion tensor imaging (DTI) measures [fractional anisotropy (FA) and radial diffusivity (RD)] of the white matter microstructure were compared between groups. We observed significant interactive effects between alcohol dependence and overweight/obesity on DTI measures in several tracts. The DTI measures were not significantly different between the overweight/obese and normal-weight groups (although widespread trends of increased FA and decreased RD were observed) among controls. However, among the alcohol-dependent patients, the overweight/obese group had widespread reductions in FA and widespread increases in RD, most of which significantly differed from the normal-weight group; among those with overweight/obesity, the alcohol-dependent group had widespread reductions in FA and widespread increases in RD, most of which were significantly different from the control group. This study found significant interactive effects between overweight/obesity and alcohol dependence on white matter microstructure, indicating that these two controllable factors may synergistically impact white matter microstructure and disrupt structural connectivity in the human brain.
关于肥胖与白质微结构改变之间的关联，证据并不一致。这种不一致的发现可能与肥胖和酒精依赖的累积效应有关。本研究旨在探讨酒精依赖与超重/肥胖对人脑白质微结构可能存在的相互作用。共纳入60例早期戒酒的酒精依赖住院患者（44例体重正常，16例超重/肥胖）和65例对照者（42例体重正常，23例超重/肥胖）。比较了两组之间白质微结构的扩散张量成像（DTI）测量值[分数各向异性（FA）和径向扩散率（RD）]。我们观察到酒精依赖与超重/肥胖在几条神经束的DTI测量值上存在显著的交互作用。在对照组中，超重/肥胖组与体重正常组之间的DTI测量值无显著差异（尽管观察到FA普遍升高和RD普遍降低的趋势）。然而，在酒精依赖患者中，超重/肥胖组FA普遍降低，RD普遍升高，其中大多数与体重正常组有显著差异；在超重/肥胖者中，酒精依赖组FA普遍降低，RD普遍升高，其中大多数与对照组有显著差异。本研究发现超重/肥胖与酒精依赖在白质微结构上存在显著的交互作用，表明这两个可控因素可能协同影响白质微结构并破坏人脑的结构连通性。
