Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain.
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
Sci Rep. 2018 Oct 26;8(1):15898. doi: 10.1038/s41598-018-34219-8.
Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.
超重和压力都与大脑结构异常有关。适应负荷模型表明，内稳态的频繁破坏与氧化应激和炎症反应有关，而这些反应反过来又会损害大脑。然而，适应负荷对中枢神经系统的影响在很大程度上仍然未知。本研究旨在评估超重人群中适应负荷与全脑白质束组成之间的关系。此外，我们还针对适应负荷增加对灰质变化进行了测试。31 名超重至肥胖成年人和 21 名正常体重成年人参与了这项研究。我们的结果表明，超重参与者的适应负荷指数较高。这种增加与下额枕束和右侧前冠状辐射的分数各向异性降低有关，也与左侧中央前回、左侧外侧枕叶和右侧额下回的灰质减少有关。这些结果表明，健康的超重状态与可能对大脑有害的长期生物学变化有关。
