Endo Go, Kanai Sachiko, Nishio Hiroto, Hashimoto Hideki, Higurashi Yoshimi, Nomura Yusuke, Nakai Yousuke, Fujishiro Mitsuhiro
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
Department of Endoscopy and Endoscopic Surgery, The University of Tokyo Hospital, Japan.
Intern Med. 2024 Oct 1;63(19):2689-2693. doi: 10.2169/internalmedicine.3036-23. Epub 2024 Feb 26.
We herein present the first known case of bacteremia caused by Kluyvera georgiana in a 67-year-old female undergoing chemotherapy for recurrent pancreatic cancer. The patient underwent choledochojejunotomy and thereafter developed ascending cholangitis. The diagnosis of K. georgiana was confirmed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. A literature review of Kluyvera spp. infections indicated potential risk factors including an underlying malignancy and immunosuppression. Although Kluyvera spp. infections are typically sensitive to antibiotics, multidrug resistance is possible. This case highlights the importance of the early diagnosis and treatment of K. georgiana and its associated risk factors.
我们在此报告首例已知的由佐治亚克吕沃尔菌引起的菌血症病例，患者为一名67岁女性，因复发性胰腺癌正在接受化疗。该患者接受了胆总管空肠吻合术，随后发生了上行性胆管炎。通过基质辅助激光解吸/电离飞行时间质谱法确诊为佐治亚克吕沃尔菌感染。对克吕沃尔菌属感染的文献综述表明，潜在风险因素包括潜在恶性肿瘤和免疫抑制。尽管克吕沃尔菌属感染通常对抗生素敏感，但也可能出现多重耐药。该病例凸显了早期诊断和治疗佐治亚克吕沃尔菌及其相关风险因素的重要性。
